反应详情

To a mixture of 1-[3-(benzyloxy)-6-chloropyridin-2-yl]ethanol (7.04 g) synthesized above, 4-methylmorpholine N-oxide (6.26 g) and acetonitrile (140 mL) was added tetrapropylammonium perruthenate (938 mg), and the mixture was stirred at room temperature for 3 hr, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (0-10% ethyl acetate/hexane) to give the title object compound (6.26 g, 90%) as a white solid.

1. concentrationconcentrated under reduced pressure
2. customThe residue was purified by silica gel column chromatography (0-10% ethyl acetate/hexane)