反应详情

General method B was applied to 4-(6-amino-5-bromopyridin-3-yl)-N-cyclopropylbenzenesulfonamide (112 mg, 0.304 mmol) and 5-carbamoylpyridin-2-ylboronic acid (75 mg, 0.453 mmol) to provide 2′-amino-5′-(4-(N-cyclopropylsulfamoyl)phenyl)-[2,3′-bipyridine]-5-carboxamide as a white solid (35 mg, 28% yield) after purification by reverse phase preparatory HPLC. 1H NMR (400 MHz, DMSO-d6) δ ppm 9.07-9.16 (m, 1H), 8.53 (d, J=2.3 Hz, 1H), 8.47 (d, J=2.3 Hz, 1H), 8.32 (dd, J=14.1, 10.8 Hz, 2H), 8.21 (br. s., 1H), 8.01 (d, J=8.5 Hz, 2H), 7.91 (d, J=2.5 Hz, 1H), 7.85 (d, J=8.3 Hz, 2H), 7.79 (br. s., 2H), 7.61 (br. s., 1H), 2.06-2.18 (m, 1H), 0.34-0.55 (m, 4H); MS (EI) m/z: 410 [M+H]+.