HRID2091571

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H]1CNc2cc(B3OC(C)(C)C(C)(C)O3)ccc2C(=O)N1

HCID70654479

未命名化合物

结构：Nc1ncc(-c2ccc(S(=O)(=O)NC3CC3)cc2)cc1Br

HCID70654595

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1CNc2cc(-c3cc(-c4ccc(S(=O)(=O)NC5CC5)cc4)cnc3N)ccc2C(=O)N1

HCID70654759

未命名化合物

收率 33%

PROCEDURE

实验过程

General method C was applied to (S)-3-methyl-8-(4,4,5,5-tetra methyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one (303 mg, 0.7 mmol) and 4-(6-amino-5-bromopyridin-3-yl)-N-cyclopropylbenzenesulfonamide to give (S)-4-(6-amino-5-(3-methyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)pyridin-3-yl)-N-cyclopropylbenzenesulfonamide as a yellow solid (180 mg, 33% yield) after purification by reverse phase preparatory HPLC. MS (EI) m/z=464.6 [M+1]+.