反应详情

3.5 g (9.4 mmol) of 2-benzo-1,2,5-thiadiazol-5-ylmethyl-6-(3,4,5-tri-fluorophenyl)-2H-pyridazin-3-one are dissolved in 35 ml of THF and hydrogenated under a hydrogen atmosphere in an autoclave at 30° C. under a pressure of 2 bar with 2 g of Raney Ni (70%, water-moist). After 17 h, a further 3 g of Raney Ni (70%, water-moist) are added, and the mixture is hydrogenated at 35° C. under a pressure of 2 bar for a further 16 h. The catalyst is separated off, rinsed, and the filtrate is evaporated to dryness.

1. waitthe mixture is hydrogenated at 35° C. under a pressure of 2 bar for a further 16 h
2. customThe catalyst is separated off
3. washrinsed
4. customthe filtrate is evaporated to dryness