反应详情

The tert-butyl 1′-(6-chloropyrimidin-4-yl)-4,4′-bipiperidine-1-carboxylate (100 mg, 0.26 mmol) was dissolved in NMP (2.6 mL), and sodium methanethiolate (18.2 mg, 0.26 mmol) was added. The reaction was stirred at r.t. for 30 min. The reaction crude was diluted with ethyl acetate (10 mL) and was washed with water (10 mL, ×1) and brine (10 mL, ×1), dried over magnesium sulfate, filtered and concentrated by rotavapor. The crude mixture was purified by preparative TLC with 30% ethylacetate:hexane to yield the title compound.

1. customThe reaction crude
2. washwas washed with water (10 mL, ×1) and brine (10 mL, ×1)
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated by rotavapor
6. customThe crude mixture was purified by preparative TLC with 30% ethylacetate