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HRID2093666

反应详情

EQUATION

反应方程式

HRID 2093666 的结构方程式

REACTANTS

反应物

6
结构：CC[C@@H](N)C(=O)O
HCID439691

D-alpha-Aminobutyric acid

C4H9NO2

结构：O=[N+]([O-])c1cnc(Cl)nc1Cl
HCID521266

2,4-Dichloro-5-nitropyrimidine

C4HCl2N3O2

结构：COC(=O)C1COCCN1
HCID3286806

Methyl 3-Morpholinecarboxylate

C6H11NO3

结构：O=C(O)C1COCCN1
HCID3340152

Morpholine-3-carboxylic Acid

C5H9NO3

结构：CC[C@@H](N)C(=O)OC
HCID13283514

未命名化合物

结构：CC[C@H](C(=O)OC)N(c1nc(Cl)ncc1[N+](=O)[O-])C1CCCC1
HCID58405447

Methyl (2R)-2-[(2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino]butanoate

C14H19ClN4O4

PRODUCTS

生成物

1
结构：CN1C(=O)C2COCCN2c2nc(Cl)ncc21
HCID58405281

未命名化合物

PROCEDURE

实验过程

Intermediate I was prepared in the same manner as Intermediate B, using 3-morpholinecarboxylic acid as the starting material instead of (R)-2-aminobutanoic acid. No reductive amination step, such as that used for the conversion of compound II to compound III, was required. Rather, methylmorpholine-3-carboxylate was reacted directly with 2,4-dichloro-5-nitropyrimidine in the same manner as is described for the conversion of compound III to Intermediate A. LCMS: 254.9 m/z (M+H)+.