Methyl bromoacetate → {4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid methyl ester

HRID 2095481Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[NH:16][CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:22][C:23]([O:25][CH3:26])=[O:24].OS([O-])(=O)=O.[K+]>C1COCC1>[CH3:26][O:25][C:23](=[O:24])[CH2:22][N:16]1[C:17](=[O:20])[CH2:18][CH2:19][N:13]([C:11](=[O:12])/[CH:10]=[CH:9]/[C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[CH2:14][CH2:15]1

Participants

Conditions

Temperature: -10 °C

Procedure

A suspension of 2.60 g (8.30 mmol) of 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 5A) in 46 ml of THF was treated slowly at −78° C. with 9.30 ml (9.30 mmol) of lithium hexamethyldisilylazide 1M in THF. After 20 min at −78° C., the mixture was warmed to nearly −10° C. to go entirely in solution and cooled to −78° C. just after. Then, a solution of 1.18 ml (12.45 mmol) of methyl bromoacetate in 15 ml of THF was added dropwise. Over night, the solution was naturally warmed to RT, poured on aqueous 10% KHSO4 solution and extracted with EtOAc(3×). The organic phase was dried (Na2SO4) and evaporated to give 3.21 g (quant.) of the titled compound as a light brown solid containing max 5% of methyl bromoacetate. MS: 385.3 (MH+, 2Cl).

Workup

temperaturecooled to −78° C. just after
waitOver night
temperaturethe solution was naturally warmed to RT
extractionextracted with EtOAc(3×)
dry with materialThe organic phase was dried (Na2SO4)
customevaporated

Sources & evidence

ORD record: ord-9ec317e6a6a645c79d9bc9cc22a98d87
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445674B2

Reaction notes

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