Methyl iodide → (S)-4-[(S)-4-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-hydroxymethyl-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethoxy-phenyl)-methyl-amide

HRID 2095574Notes

Reaction equation

HRID 2095574 reaction equation
I[CH3:2].[Cl:3][C:4]1[CH:5]=[C:6]([NH:15][C:16]([N:18]2[CH2:23][CH2:22][N:21]([C@H:24]([CH2:38][OH:39])[CH2:25][CH2:26][C:27]([N:29]3[CH2:36][CH2:35][C:32]4([CH2:34][CH2:33]4)[C@H:31]([OH:37])[CH2:30]3)=[O:28])[C:20](=[O:40])[C@@H:19]2[CH3:41])=[O:17])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12]>C(#N)C.[Ag-]=O>[Cl:3][C:4]1[CH:5]=[C:6]([N:15]([CH3:2])[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C@H:24]([CH2:38][OH:39])[CH2:25][CH2:26][C:27]([N:29]3[CH2:36][CH2:35][C:32]4([CH2:33][CH2:34]4)[C@H:31]([OH:37])[CH2:30]3)=[O:28])[C:20](=[O:40])[C@@H:19]2[CH3:41])=[O:17])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:13])([F:14])[F:12]

Participants

5

Reactant 2

HCID 6328Methyl iodide2×HCID 58232125(S)-4-[(S)-4-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-hydroxymethyl-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethoxy-phenyl)-amide

Product 1

HCID 58232111(S)-4-[(S)-4-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-hydroxymethyl-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethoxy-phenyl)-methyl-amideYield 88%

Reagents, catalysts & solvents 2

HCID 178418778HCID 178418778, compoundCatalystHCID 6342AcetonitrileSolvent

Procedure

A solution of 0.02 ml (0.345 mmol) of iodomethane and 0.040 g (0.069 mmol) (S)-4-[(S)-4-(S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-hydroxymethyl-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethoxy-phenyl)-amide (example 55) in 1.5 ml of acetonitrile was cooled (0° C.) and treated with 0.023 g (0.100 mmol) of silver(I) oxide. The reaction mixture was stirred at RT for 1 day, treated again with 0.02 ml (0.345 mmol) of iodomethane and stirred for 3 days. The reaction was partitioned between aqueous 10% KHSO4/EtOAc (3×). The organic phases were washed with aqueous saturated NaHCO3, aqueous 10% NaCl, dried (Na2SO4) and evaporated to give 0.040 g (88%) of the titled compound as off-white foam. MS: 591.22 (MH+, Cl).

Workup

  1. stirringstirred for 3 days
  2. customThe reaction was partitioned between aqueous 10% KHSO4/EtOAc (3×)
  3. washThe organic phases were washed with aqueous saturated NaHCO3, aqueous 10% NaCl
  4. dry with materialdried (Na2SO4)
  5. customevaporated

Sources & evidence

ORD record
ord-a9ca6941682142fda54d52887a86d20e
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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