反应详情

The title compound was also prepared as follows: A solution of methyl 3-((7-(4-chlorophenyl)-3-oxo-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)methyl)-6-(trifluoromethyl)picolinate (60 mg, 0.11 mmol) in a mixture of 1 M aqueous NaOH (1 mL) and THF (1 mL) was stirred at room temperature for 4 h. After cooling to 0° C., the reaction mixture was neutralized to pH 6-7 by addition of 1 M aqueous HCl solution, then extracted with EtOAc (30 mL×3). The combined EtOAc extracts were washed with saturated aqueous NaCl, dried (Na2SO4), filtered, and concentrated under reduced pressure to afford the title compound.

1. temperatureAfter cooling to 0° C.
2. extractionextracted with EtOAc (30 mL×3)
3. washThe combined EtOAc extracts were washed with saturated aqueous NaCl
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure