反应详情

Borane-tetrahydrofuran complex (1M in THF) (200 ml, 0.19 mol) was added dropwise to the morpholin-3-one from example 5 (15.8 g, 0.06 mol) in dry THF (100 ml) under an atmosphere of nitrogen, over 30 minutes. The reaction mixture was brought to reflux for 3 hours then cooled and quenched by addition of methanol (30 ml). The reaction mixture was then concentrated in vacuo and the colourless residue cautiously suspended in 4N HCl (aq) (400 ml) before refluxing for 2.5 hours. The reaction mixture was cooled and dichloromethane (200 ml) added. Layers were separated and the aqueous layer rendered basic by addition of potassium carbonate before re-extracting with dichloromethane (3×100 ml). The organic extracts were combined, dried over anhydrous magnesium sulphate, filtered and concentrated in vacuo to give the title compound as a colourless oil (12.51 g, 0.05 mol, 84%). 1H NMR (CDCl3, 400 MHz) δ: 0.95 (t, 3H), 1.59 (q, 2H), 2.05 (t, 1H), 2.23 (t, 1H), 2.40 (t, 2H), 2.81 (d,1H), 2.98 (d1H), 3.80 (s, 3H), 3.85 (t, 1H), 4.05 (d, 1H), 4.60 (d, 1H), 6.81 (d, 1H), 6.91 (d, 1H), 7.21 (t, 1H), 7.23 (s, 1H). LRMS: m/z 236. Analysis found C, 68.94; H, 8.80; N, 5.79%. C14H21NO2.0.5H2O requires C, 68.82; H, 9.08; N, 5.73%.

1. temperatureto reflux for 3 hours
2. temperaturethen cooled
3. customquenched by addition of methanol (30 ml)
4. concentrationThe reaction mixture was then concentrated in vacuo
5. temperaturebefore refluxing for 2.5 hours
6. temperatureThe reaction mixture was cooled
7. additiondichloromethane (200 ml) added
8. customLayers were separated
9. additionthe aqueous layer rendered basic by addition of potassium carbonate
10. extractionbefore re-extracting with dichloromethane (3×100 ml)
11. dry with materialdried over anhydrous magnesium sulphate
12. filtrationfiltered
13. concentrationconcentrated in vacuo