反应详情

N-{5-[4-(5-Methylpyrazol-3-ylamino)pyrimidin-2-ylamino]benzothiazol-2-yl}benzamide was prepared by beating a mixture of N-(5-aminobenzothiazol-2-yl)benzamide (IM 5, 35 mg, 0.13 mmol) and (2-chloropyrimidin-4-yl)-(5-methylpyrazol-3-yl)amine (IM 11, 30 mg, 0.143 mmol) in ethanol (3 mL) to 80° C. for 9 h. The precipitate was separated by filtration, washed with ethanol and dried (32 mg, 72 μmol, 56%) LC/ESI-MS: m/z=443 [M+H]+; m/z 441 [M−H]−; Rt=2.92 min.

1. customThe precipitate was separated by filtration
2. washwashed with ethanol
3. customdried (32 mg, 72 μmol, 56%) LC/ESI-MS