反应详情

To a solution of 2-(3-bromophenyl)-2-methyl-[1,3]dioxolane (1 g) in THF (5 mL) was added portionwise magnesium metal (0.2 g) and the reaction heated at refluxed for 30 minutes. The mixture was cooled to room temperature and CuBr-DMS complex (846 mg, 4.11 mmol) was added. The mixture was stirred 3 minutes at room temperature, cooled to 0° C. and 1,1,1-trifluoro-4-methylpent-3-en-2-one (62 mg, 4.11 mmol) in 20 mL of THF was added dropwise. The mixture was stirred for 30 minutes at 0° C., warmed to room temperature, stirred overnight and quenched with aqueous ammonium chloride solution and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford a residue that was purified by flash chromatography. Concentration in vacuo of the product-rich fractions afforded 0.56 g of 1,1,1-trifluoro-4-methyl-4-[3-(2-methyl-[1,3]dioxolan-2-yl)phenyl]pentan-2-one.

1. temperaturethe reaction heated
2. temperatureat refluxed for 30 minutes
3. additionCuBr-DMS complex (846 mg, 4.11 mmol) was added
4. temperaturecooled to 0° C.
5. stirringThe mixture was stirred for 30 minutes at 0° C.
6. temperaturewarmed to room temperature
7. stirringstirred overnight
8. customquenched with aqueous ammonium chloride solution and ethyl acetate
9. washThe organic layer was washed with brine
10. dry with materialdried over sodium sulfate
11. concentrationconcentrated in vacuo
12. customto afford a residue that
13. customwas purified by flash chromatography
14. concentrationConcentration in vacuo of the product-rich fractions