HCID 86599050, compound → HCID 68854382, compound

HRID 2112868Notes

Reaction equation

HRID 2112868 reaction equation
[ClH:1].Cl.C(OC1C=CC(C(N2CC[C@@H](NC)C2)CC2(O)CCCCC2)=CC=1)C1C=CC=CC=1.C(O[C:38](=O)[NH:39][C@@H:40]1[CH2:44][CH2:43][N:42]([C:45](=O)[CH:46]([C:54]2[CH:59]=[CH:58][C:57]([O:60][CH2:61][C:62]3[CH:67]=[CH:66][CH:65]=[CH:64][CH:63]=3)=[CH:56][CH:55]=2)[C:47]2([OH:53])[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]2)[CH2:41]1)(C)(C)C>>[ClH:1].[ClH:1].[CH2:61]([O:60][C:57]1[CH:58]=[CH:59][C:54]([CH:46]([C:47]2([OH:53])[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]2)[CH2:45][N:42]2[CH2:43][CH2:44][C@@H:40]([NH:39][CH3:38])[CH2:41]2)=[CH:55][CH:56]=1)[C:62]1[CH:63]=[CH:64][CH:65]=[CH:66][CH:67]=1

Participants

3

Reactant 2

HCID 86599050HCID 86599050, compoundHCID 86599052HCID 86599052, compound

Product 1

HCID 68854382HCID 68854382, compound

Procedure

In an analogous manner to Example 13, step 2,1-{1-[4-(benzyloxy)phenyl-2-[(3R)-3-(methylamino)pyrrolidin-1-yl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl{(3R)-1-[[4-(benzyloxy)phenyl](1-hydroxycyclohexyl)acetyl]pyrrolidin-3-yl}carbamate. MS m/z 409; HRMS: calcd for C26H36N2O2+H+, 409.28495; found (ESI, [M+H]+), 409.2876.

Sources & evidence

ORD record
ord-092a76cfe8fd4b57bb7ee0f89f2331da
Source dataset
uspto-grants-2009_04
Patent number
US07524846B2

Reaction notes

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