反应详情

30 g of 3-(5-Hydroxy-5-phenyl-pentanoyl)-4-phenyl-oxazolidin-2-on are solved in 50 ml of DMF. After addition of 14.3 g of imidazol and 19 g of tert. -Butyl-dimethylsilylchlorid in 25 ml of DMF the reaction is stirred at room temperature until all components are dissolved (2-4 h). The reaction solution is evaporated, and after water was added extracted by acetic acid ethylester. After drying of the organic phase by magnesium sulfate and evaporation compound I (product 1) is obtained: C26H35NO4Si (453.6) MS (ESI+) 476 (M+Na+).

1. dissolutionare dissolved (2-4 h)
2. customThe reaction solution is evaporated
3. additionafter water was added
4. extractionextracted by acetic acid ethylester
5. dry with materialAfter drying of the organic phase by magnesium sulfate
6. customevaporation compound I (product 1)
7. customis obtained