反应详情

Next, a mixture of (4-methoxycarbonylphenyl)-[3-(methoxymethoxy)pyridin-4-yl]-methanol (2.06 g, 6.79 mmol), methanol (35 mL) and concentrated hydrochloric acid (4.4 mL) was heated under reflux for 20 minutes. After cooling to room temperature, the reaction mixture was concentrated. Methanol and ethyl acetate were added to the residue and the resulting precipitate was filtered to give (4-methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride (1.87 g, 81%).

1. temperaturewas heated
2. temperatureunder reflux for 20 minutes
3. concentrationthe reaction mixture was concentrated
4. additionMethanol and ethyl acetate were added to the residue
5. filtrationthe resulting precipitate was filtered