反应详情

Employing the procedure of Example 1, Step 3, using 7-bromo-4-(4-fluorophenyl)-2H-chromen-2-one (0.467 g, 1.5 mmol), (3S)-4,4,4-trifluoro-3-hydroxy-3-(2-mercapto-1,3-thiazol-5-yl)butanoic acid (enantiomer #1, 0.400 g, 1.5 mmol) and potassium carbonate (0.708 g, 5.1 mmol) in NMP at 120° C., the title compound was obtained. Purification was done on silica gel (CH2Cl2/MeOH/HOAc; 90:10:0.5). [α]25D−30° (c=0.5, CHCl3). 1H NMR (400 MHz, acetone-d6): δ 7.99 (s, 1H), 7.68 (m, 2H), 7.58 (m, 2H), 7.48 (dd, 1H), 7.39 (dd, 2H), 6.43 (s, 1H), 3.33 (dd, 2H).

1. customat 120° C.