反应详情

The title compound was produced following the procedure of Example 1 using 12.0 g (26 mmol) of 3-[5-[4-(3-trifluoromethylphenyl)piperazin-1-yl]pentyl]thieno[3,4-d]pyrimidine-2,4-dione in DMF at 50° C. for 24 hours to produce methyl 3-[3-[5-[4-(3-trifluoromethylphenyl)piperazin-1-yl]pentyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]propanoate in 41% yield (5.78 g) after recrystallization from ether/hexane, mp 99.5°-101° C.

1. customat 50° C.
2. customfor 24 hours