7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 1-Ethyl-6-fluoro 1,4-dihydro-7-[3-[(4-methyl-1-piperazinyl)methyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid

HRID 2165605ノート

反応式

HRID 2165605 の反応式
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:17])[C:7]([C:14]([OH:16])=[O:15])=[CH:8][N:9]2[CH2:12][CH3:13])=[CH:4][C:3]=1[F:18].[CH3:19][N:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH:27]2[CH2:32][NH:31][CH2:30][CH2:29][NH:28]2)[CH2:22][CH2:21]1>N1C=CC=CC=1>[CH2:12]([N:9]1[C:10]2[C:5](=[CH:4][C:3]([F:18])=[C:2]([N:31]3[CH2:30][CH2:29][NH:28][CH:27]([CH2:26][N:23]4[CH2:22][CH2:21][N:20]([CH3:19])[CH2:25][CH2:24]4)[CH2:32]3)[CH:11]=2)[C:6](=[O:17])[C:7]([C:14]([OH:16])=[O:15])=[CH:8]1)[CH3:13]

参加物

4

反応物 2

HCID 4831697-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 197635601-Methyl-4-(2-piperazinylmethyl)piperazine

生成物 1

HCID 197635961-Ethyl-6-fluoro 1,4-dihydro-7-[3-[(4-methyl-1-piperazinyl)methyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A 425 mg portion of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.25 g of 1-methyl-4-(2-piperazinylmethyl)piperazine were suspended in 5 ml of pyridine and heated at reflux, under argon, for 18 hours. The solvents were removed and the residue evaporated twice from toluene. The residue was dissolved in dichloromethane, hexane was added, the resulting gum was separated, dissolved in dichloromethane and filtered. Ether was added to the filtrate, the resulting solid collected and recyrstallized, giving 360 mg of the desired product as a yellow solid.

後処理

  1. temperatureheated
  2. temperatureat reflux, under argon, for 18 hours
  3. customThe solvents were removed
  4. customthe residue evaporated twice from toluene
  5. dissolutionThe residue was dissolved in dichloromethane
  6. additionhexane was added
  7. customthe resulting gum was separated
  8. dissolutiondissolved in dichloromethane
  9. filtrationfiltered
  10. additionEther was added to the filtrate
  11. customthe resulting solid collected

出典と根拠

ORDレコード
ord-6bdebb9193ab43e0a84ac4b96aef7121
出典データセット
uspto-grants-1990_07
特許番号
US04940710

反応ノート

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