反应详情

A 425 mg portion of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.25 g of 1-methyl-4-(2-piperazinylmethyl)piperazine were suspended in 5 ml of pyridine and heated at reflux, under argon, for 18 hours. The solvents were removed and the residue evaporated twice from toluene. The residue was dissolved in dichloromethane, hexane was added, the resulting gum was separated, dissolved in dichloromethane and filtered. Ether was added to the filtrate, the resulting solid collected and recyrstallized, giving 360 mg of the desired product as a yellow solid.

1. temperatureheated
2. temperatureat reflux, under argon, for 18 hours
3. customThe solvents were removed
4. customthe residue evaporated twice from toluene
5. dissolutionThe residue was dissolved in dichloromethane
6. additionhexane was added
7. customthe resulting gum was separated
8. dissolutiondissolved in dichloromethane
9. filtrationfiltered
10. additionEther was added to the filtrate
11. customthe resulting solid collected