反应详情

13 g (565 mmol) of sodium are added in portions to 410 ml of ethanol. After it has dissolved completely, 107 g (545 mmol) of 4-(p-chlorophenyl)-2-oxopyrrolidine are added, the whole is stirred at room temperature for 2 hours, concentrated to dryness by evaporation under reduced pressure and dried overnight at 100° under reduced pressure. The resulting sodium 4-(p-chlorophenyl)-2-oxopyrrolidine is made into a slurry in 340 ml of toluene, and a solution of 63.7 ml (95.9 g; 574 mmol) of bromoacetic acid ethyl ester is added dropwise, while stirring, at 20° to 25°. The whole is stirred for a further 16 hours, concentrated to dryness by evaporation under reduced pressure at approximately 70° and partitioned between 300 ml of water and 600 ml of ethyl acetate. The organic phase is separated off, washed with saturated sodium chloride solution, dried over sodium sulphate, filtered and concentrated to dryness by evaporation under reduced pressure. 2-[4-(p-chlorophenyl)-2-oxopyrrolidin-1-yl]-acetic acid ethyl ester is obtained which, for purification, is distilled under reduced pressure; b.p.=176°-178° at 0.02 torr (0.027 mbar).

1. dissolutionAfter it has dissolved completely
2. concentrationconcentrated to dryness by evaporation under reduced pressure
3. customdried overnight at 100° under reduced pressure
4. stirringwhile stirring, at 20° to 25°
5. stirringThe whole is stirred for a further 16 hours
6. concentrationconcentrated to dryness by evaporation under reduced pressure at approximately 70°
7. custompartitioned between 300 ml of water and 600 ml of ethyl acetate
8. customThe organic phase is separated off
9. washwashed with saturated sodium chloride solution
10. dry with materialdried over sodium sulphate
11. filtrationfiltered
12. concentrationconcentrated to dryness by evaporation under reduced pressure