反应详情

N-(1-(2-bromo-4-chlorophenyl)ethyl)-4′-chloro-[1,1′-biphenyl]-4-amine (129 mg, 0.31 mmol), 4-(ethoxycarbonyl)phenylboronic acid (89 mg, 0.46 mmol), Pd(dppf) Cl2 (34 mg, 0.05 mmol), and K2CO3 (106 mg, 0.76 mmol) in wet DMF (3 mL) was heated to 90° C. After 16 h the resulting mixture was cooled to room temperature and filtered. The filtrate was diluted with EtOAc, washed with water for and saturated aqueous NaHCO3, dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

1. filtrationfiltered
2. additionThe filtrate was diluted with EtOAc
3. washwashed with water for and saturated aqueous NaHCO3
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. custompurified via column chromatography