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HRID216764

反应详情

EQUATION

反应方程式

HRID 216764 的结构方程式

REACTANTS

反应物

2
结构：O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Ce+4].[NH4+]
HCID9869224

未命名化合物

结构：COc1ccc(CNCc2cc3cccc(C)c3nc2-c2ccccc2C(F)(F)F)cc1
HCID57707763

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cccc2cc(CN)c(-c3ccccc3C(F)(F)F)nc12
HCID57707817

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N.O
溶剂HCID18373917

Acetonitrile--water (1/1)

C2H5NO

PROCEDURE

实验过程

Prepared according to Procedure G using N-(4-methoxybenzyl)(8-methyl-2-(2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine (1.1427 g, 2.62 mmol, 1 eq) and ammonium cerium(iv) nitrate (3.59 g, 6.55 mmol, 2.5 eq) in CH3CN—H2O (2:1, 12 mL). After purification, (8-methyl-2-(2-(trifluoromethyl)phenyl)quinolin-3-yl)methanamine was obtained as brown syrup. 1H NMR (DMSO-d6) δ ppm 8.47 (1H, s), 7.91 (1H, d, J=7.4 Hz), 7.84 (1H, d, J=7.4 Hz), 7.67-7.81 (2H, m), 7.47-7.62 (3H, m), 3.46-3.70 (2H, m), 2.61 (3H, s), 1.86 (2H, br. s.). Mass Spectrum (ESI) m/e=317.0 (M+1).

WORKUP

后处理

  1. customPrepared
  2. customAfter purification