反应详情

To a stirred solution of 5-benzyloxy-2-biphenyl-2-ylmethyl-6-hydroxypyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-methyl-amide (9-01) (2.1 g, 3.602 mmol) in tetrahydrofuran (30 mL) was added 1N HCl (5.4 ml, 5.4 mmol) at room temperature. The mixture was stirred for 60 min at room temperature. After completion of the reaction, the mixture was neutralized with 1N sodium hydroxide aqueous solution, extracted with ethyl acetate, dried over sodium sulfate and concentrated under reduced pressure to get a crude product which was purified using a normal silica column using 60% ethyl acetate in hexane to get 5-benzyloxy-2-biphenyl-2-ylmethyl-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)-methyl-amide (10-01) (900 mg, 53.33%) as a floppy light yellow solid.

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customto get a crude product which
6. customwas purified