HRID2169401

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)OCCN(C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1)C1CCOCC1

HCID178455270

未命名化合物

结构：CN(CCO)C(=O)c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1

HCID178484637

未命名化合物

PRODUCTS

生成物

结构：O=C(c1nc(CC2(c3cccc4ccccc34)CCCC2)nc(O)c1OCc1ccccc1)N(CCO)C1CCOCC1

HCID178519958

未命名化合物

PROCEDURE

实验过程

This compound was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid (2-hydroxyethyl)-methyl-amide (351) from 5-benzyloxy-6-hydroxy-2-(1-naphthalen-1-yl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-(tetrahydro-pyran-4-yl)-amide (366) (300 mg, 0.43 mmol). The yield was 140 mg, 56%, of a white solid.

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-200b6dd32cea469d8f75cb126a044623
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

OCCN(C)C(C1C(OCC2C=CC=CC=2)=C(O)N=C(CC2(C3C4C(=CC=CC=4)C=CC=3)CCCC2)N=1)=O.[Si]([O:46][CH2:47][CH2:48][N:49]([CH:83]1[CH2:88][CH2:87][O:86][CH2:85][CH2:84]1)[C:50]([C:52]1[C:57]([O:58][CH2:59][C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)=[C:56]([OH:66])[N:55]=[C:54]([CH2:67][C:68]2([C:73]3[C:82]4[C:77](=[CH:78][CH:79]=[CH:80][CH:81]=4)[CH:76]=[CH:75][CH:74]=3)[CH2:72][CH2:71][CH2:70][CH2:69]2)[N:53]=1)=[O:51])(C(C)(C)C)(C)C>>[OH:46][CH2:47][CH2:48][N:49]([CH:83]1[CH2:84][CH2:85][O:86][CH2:87][CH2:88]1)[C:50]([C:52]1[C:57]([O:58][CH2:59][C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)=[C:56]([OH:66])[N:55]=[C:54]([CH2:67][C:68]2([C:73]3[C:82]4[C:77](=[CH:78][CH:79]=[CH:80][CH:81]=4)[CH:76]=[CH:75][CH:74]=3)[CH2:72][CH2:71][CH2:70][CH2:69]2)[N:53]=1)=[O:51]