反应详情

(S)-tert-Butyl 4-(2-(4′-carbamoyl-3′-fluorobiphenyl-4-yl)-1-cyanoethylcarbamoyl)tetrahydro-2H-pyran-4-ylcarbamate (Example 25, step (i), 108 mg) in formic acid (2 mL) was heated at 50° C. for 20 mins. Volatiles were removed under reduced pressure and the residue azeotroped with methanol. The residue was purified by reversed phase HPLC using methanol in 0.1% aqueous TFA solution as eluent. The residue was converted to the free base by elution through a PL-HCO3 MP cartridge in dichloromethane/methanol to afford the titled compound (53 mg).

1. customVolatiles were removed under reduced pressure
2. customthe residue azeotroped with methanol
3. customThe residue was purified by reversed phase
4. washThe residue was converted to the free base by elution through a PL-HCO3 MP cartridge in dichloromethane/methanol