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HRID2170400

反应详情

EQUATION

反应方程式

HRID 2170400 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)Cn1nc(C(F)(F)F)c2c1C(F)(F)[C@@H]1C[C@H]21
HCID90281286

(3bS,4aR)-5,5-Difluoro-3b,4,4a,5-tetrahydro-3-(trifluoromethyl)-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazole-1-acetic acid

C10H7F5N2O2

结构：CN(CCO)c1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(C)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1
HCID90281434

未命名化合物

PRODUCTS

生成物

1
结构：CN(CCO)c1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(C)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1
HCID90290152

未命名化合物

PROCEDURE

实验过程

The title compound (58) was prepared according to the method presented for the synthesis of compound 57G of Example 57 utilizing 2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetic acid (30J). 1H NMR (400 MHz, Methanol-d4) δ 7.43-6.05 (m, 7H), 5.18-5.09 (m, 1H), 4.85-4.75 (m 2H), 4.04-3.69 (m, 3H), 3.42 (s, 2H), 3.27-3.20 (m, 6H), 3.20-3.11 (m, 2H), 3.05 (s, 1H), 2.95 (s, 1H), 2.61-2.43 (m, 2H), 1.51-1.35 (m, 1H), 1.11 (m, 1H). MS (m/z) 829.20 [M+H]+.