反应详情

The title compound was prepared in a procedure analogous to Intermediate I, wherein 8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (Intermediate R) was substituted for 5-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride [M+H]+=524.0 1H NMR (400 MHZ, Acetone-d6) δ ppm: 7.97 (s, 1H), 7.91 (dd, J=7.9, 1.0 Hz, 1H), 7.70 (d, J=8.0 Hz, 1H), 7.48 (d, J=1.0 Hz, 1H), 7.44 (t, J=1.3 Hz, 1H), 7.10-7.19 (m, 2H), 6.97-7.02 (m, 3H), 4.28-4.41 (m, 2H), 3.68-3.77 (m, 1H), 3.21-3.32 (m, 1H), 2.44-2.54 (m, 2H)