反应详情

4-Methyl-5-[2-(4-{[3-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl]carbonyl}piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one was prepared starting from 3-(1H-tetrazol-1-yl)-6,7-dihydro-5H-cyclopenta[c]pyridine-7-carboxylic acid and 4-methyl-5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride in an analogous fashion to that described by GENERAL METHOD B. The resulting mixture of two enantiomers was separated by preparative chiral SFC HPLC using a ChiralPak AD-H 250×30 mm I.D. column and eluting with A: SF CO2 and B: ethanol/acetonitrile (2:1) (0.1% DEA) with flow rate of 50 mL/min. The single title isomers were obtained.

1. additionThe resulting mixture of two enantiomers
2. customwas separated by preparative chiral SFC HPLC
3. washcolumn and eluting with A: SF CO2 and B
4. customThe single title isomers were obtained