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HRID2177240

反应详情

EQUATION

反应方程式

HRID 2177240 反应方程式

REACTANTS

反应物

2
HCID 20748401 分子结构式
HCID20748401

未命名化合物

HCID 90418265 分子结构式
HCID90418265

未命名化合物

PRODUCTS

产物

1
3-(4-[[3-(4-Chlorophenyl)-5-(trifluoromethyl)-1,2-thiazol-4-yl]methoxy]phenyl)-2-methylpropanoic acid 分子结构式
HCID90417633

3-(4-[[3-(4-Chlorophenyl)-5-(trifluoromethyl)-1,2-thiazol-4-yl]methoxy]phenyl)-2-methylpropanoic acid

C21H17ClF3NO3S

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in Example 1 following Steps 5 and 6 by coupling (3-(4-chlorophenyl)-5-(trifluoromethyl)isothiazol-4-yl)methyl methanesulfonate and ethyl 3-(4-hydroxyphenyl)-2-methyl-propanoate followed by hydrolysis to afford the desired product as an off-white solid. 1H NMR (300 MHz, CD3OD) δ: 7.71 (d, J=8.8 Hz, 2H), 7.48 (d, J=8.4 Hz, 2H), 7.16 (d, J=8.4 Hz, 1H), 6.87 (d, J=8.4 Hz, 1H), 5.09 (s, 2H), 2.93-2.98 (m, 1H), 2.63-2.74 (m, 2H), 1.15 (d, J=6.8 Hz, 3H). Mass spectrum (ESI, m/z): Calcd. for C21H17ClF3NO3S, 454.0 (M−H). found 454.0.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customfollowed by hydrolysis