反应详情

Sodium azide (177 mg) and copper (II) acetate (99.2 mg) were added to a solution of (±)-N,N-di(tert-butyloxycarbonyl)-[(4aR*,8aR*)-8a-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-thiophen-2-yl]-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-yl]amine (790 mg) in methanol (88 ml). The mixture was stirred at room temperature overnight, and then the excess of methanol was evaporated under reduced pressure. An ammonium chloride solution was added to the residue, and the aqueous layer was with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by NH-silica gel column chromatography to obtain the title compound (503 mg).

1. customthe excess of methanol was evaporated under reduced pressure
2. additionAn ammonium chloride solution was added to the residue
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by NH-silica gel column chromatography