HRID2180132

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14878596

2-Methyl-1H-indol-6-ol

C9H9NO

结构：COc1cc2c(Cl)cnnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1

HCID22490018

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(Oc3ccc4cc(C)[nH]c4c3)cnnc2cc1OCC1CCN(C(=O)OC(C)(C)C)CC1

HCID22490038

未命名化合物

PROCEDURE

实验过程

Using an analogous procedure to that described in Example 8, 7-(1-tert-butoxycarbonylpiperidin-4-ylmethoxy)-4-chloro-6-methoxycinnoline (204 mg, 0.5 mmol) was reacted with 6-hydroxy-2-methylindole (100 mg, 0.55 mmol) to give 7-(1-(tert-butoxycarbonyl)piperidin-4-ylmethoxy)-6-methoxy-4-(2-methylindol-6-yloxy)cinnoline. The crude product was then treated with TFA to give 6-methoxy-4-(2-methylindol-6-yloxy)-7-(piperidin-4-ylmethoxy)cinnoline (10 mg, 4%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1cd292265e54425e9738bd80b7c271c3
来源数据集: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06887874B2
来源说明: uspto-grants-2005_05

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:25]=[C:24]3[C:19]([C:20](Cl)=[CH:21][N:22]=[N:23]3)=[CH:18][C:17]=2[O:27][CH3:28])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH:29][C:30]1[CH:38]=[C:37]2[C:33]([CH:34]=[C:35]([CH3:39])[NH:36]2)=[CH:32][CH:31]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:25]=[C:24]3[C:19]([C:20]([O:29][C:30]4[CH:38]=[C:37]5[C:33]([CH:34]=[C:35]([CH3:39])[NH:36]5)=[CH:32][CH:31]=4)=[CH:21][N:22]=[N:23]3)=[CH:18][C:17]=2[O:27][CH3:28])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]