反应详情

Following General Procedure G, a solution of ethyl (2E,4E,6E)-7-(7-ethoxy-2,2-dimethyl-4-phenyl-2H-chromen-6-yl)-6-fluoro-3-methyl-octa-2,4,6-trienoate (Compound 114, 147 mg, 0.31 mmol) was hydrolyzed with NaOH to yield a yellow oil after purification by column chromatography (silica gel, 100% hexane to 5% to 50% ethyl acetate in hexanes). The resulting oil was recrystallized from acetonitrile to produce the title compound as a yellow solid.

1. customto yield a yellow oil
2. customafter purification by column chromatography (silica gel, 100% hexane to 5% to 50% ethyl acetate in hexanes)
3. customThe resulting oil was recrystallized from acetonitrile