反应详情

A mixture of methyl 3-(4-acetoxy-2-chlorobenzyl)-2,7-dimethyl-3H-imidazo[4,5-b]pyridine-5-carboxylate (6.5 g), conc. sulfuric acid (3.0 ml) and methanol (60 ml) was refluxed under heating for 1.5 hr. The reaction mixture was diluted with chloroform (60 ml) and saturated aqueous sodium hydrogen carbonate solution was gradually added under ice-cooling. The organic layer was separated, dried over magnesium sulfate, and concentrated to dryness under reduced pressure. The residue was washed with diethyl ether to give methyl 3-(2-chloro-4-hydroxybenzyl)-2,7-dimethyl-3H-imidazo[4,5-b]pyridine-5-carboxylate (3.81 g) as a pale-yellow powder.

1. temperaturewas refluxed
2. temperatureunder heating for 1.5 hr
3. additionwas gradually added under ice-
4. temperaturecooling
5. customThe organic layer was separated
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated to dryness under reduced pressure
8. washThe residue was washed with diethyl ether