反应详情

温度

0 °C

A 500 mL flask was charged with 15.2 g (45.4 mmol) trans-[4-(methoxy-methyl-carbamoyl)-cyclohexylmethyl]-carbamic acid benzyl ester and 350 mL anhydrous THF. The soluton was cooled to 0° C. then 33.3 mL (99.9 mmol) 3M CH3MgCl was added dropwise over 10 minutes. The reaction mixture was then stirred for 1 hour at 0° C. then quenched with 20 mL 2N acetic acid and poured into 300 mL water. The aqueous was extracted with ethyl acetate (3×200 mL) and the combined organics were washed with 0.5M HCl (1×100 mL), water (1×100 mL), brine (1×100 mL), dried over Na2SO4 and concentrated to a solid. The solid was recrystalized from IPE and filtered to give 5.5 g of a white solid.

1. customthen quenched with 20 mL 2N acetic acid
2. additionpoured into 300 mL water
3. extractionThe aqueous was extracted with ethyl acetate (3×200 mL)
4. washthe combined organics were washed with 0.5M HCl (1×100 mL), water (1×100 mL), brine (1×100 mL)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated to a solid
7. customThe solid was recrystalized from IPE
8. filtrationfiltered