反应详情

The title compound was prepared from N-[1-(2′,5′-difluoro-1,1′-biphenyl-2-yl)ethyl]-4-methoxybenzenesulfonamide (450 mg, 1.1 mmol), anhydrous N,N-dimethylformamide (2 mL), and potassium carbonate (304 mg, 2.2 mmol) according to the procedure and in the same manner as described in Example 105, step d. The product was purified by preparative column chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g), eluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min), to afford the desired compound (280 mg, 65%) as a white solid, m.p. 167-168° C.;

1. customThe product was purified by preparative column chromatography on a Biotage® 40 Mi column of prepacked silica gel (90 g)
2. washeluting with a gradient of 30%-50% methyl tert-butyl ether in hexane (35 min)