Sodium Chloride → 5-(5-Fluoro-2-methoxyphenyl)-5-methyl-2-(2-methylquinolin-5-ylimino)-3-(trifluoromethyl)hexan-3-ol

HRID 2182747Notes

Reaction equation

HRID 2182747 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH3:22])=[C:6]([C:8]([CH3:20])([CH3:19])[CH2:9][C:10]([OH:18])([C:14]([F:17])([F:16])[F:15])[C:11](=O)[CH3:12])[CH:7]=1.[NH2:23][C:24]1[CH:33]=[CH:32][CH:31]=[C:30]2[C:25]=1[CH:26]=[CH:27][C:28]([CH3:34])=[N:29]2.[Na+].[Cl-].C(OCC)(=O)C>O1CCCC1.[Ti]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][CH3:22])=[C:6]([C:8]([CH3:20])([CH3:19])[CH2:9][C:10]([C:14]([F:16])([F:17])[F:15])([OH:18])[C:11](=[N:23][C:24]2[CH:33]=[CH:32][CH:31]=[C:30]3[C:25]=2[CH:26]=[CH:27][C:28]([CH3:34])=[N:29]3)[CH3:12])[CH:7]=1

Participants

7

Reactant 4

HCID 5234Sodium ChlorideHCID 8857Ethyl Acetate2×HCID 1486835-Quinolinamine, 2-methyl-HCID 219488285-(5-Fluoro-2-methoxyphenyl)-3-hydroxy-5-methyl-3-(trifluoromethyl)hexan-2-one

Product 1

HCID 219489245-(5-Fluoro-2-methoxyphenyl)-5-methyl-2-(2-methylquinolin-5-ylimino)-3-(trifluoromethyl)hexan-3-olYield 62.5%

Reagents, catalysts & solvents 2

HCID 23963TitaniumCatalystHCID 8028TetrahydrofuranSolvent2×

Procedure

645 mg (2 mmol) of 5-(5-fluoro-2-methoxyphenyl)-3-hydroxy-5-methyl-3-(trifluoromethyl) hexan-2-one is refluxed in 4 ml of tetrahydrofuran under nitrogen with 0.84 ml (4 mmol) of titanium tetraethylate and 348 mg (2.2 mmol) of 5-amino-2-methylquinoline for 24 hours. After cooling to room temperature, the reaction mixture is stirred into 20 ml of saturated NaCl solution, 50 ml of ethyl acetate is added, and it is stirred for 30 minutes, suctioned off on Celite, and rewashed with ethyl acetate and with tetrahydrofuran. The organic phase is separated, dried (sodium sulfate) and concentrated by evaporation. Chromatography on silica gel with hexane-ethyl acetate yields 578 mg of the product.

Workup

  1. additionis added
  2. customThe organic phase is separated
  3. dry with materialdried (sodium sulfate)
  4. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-3a8629c4e5104bb7b42839c22c058adf
Source dataset
uspto-grants-2005_05
Patent number
US06897224B2

Reaction notes

Loading…