反应详情

To a solution of 3.5 g of (+) threo 1-(p-nitrophenyl)-2-(4-benzylpiperidin-1-yl)-1-aminopropan-1-ol in 35 ml of ethanol and 9 ml of 2 M hydrochloric acid and 5 ml of formaldehyde 40% solution was added portionwise 1.1 g or sodiumcyanoborohydride. After stirring 1 h, the solution was diluted with ethylacetate and basified with a concentrated ammonium hydroxide solution. The organic phase was dried and the solvent removed, affording 3.8 g of (+) threo 1-(p-nitro-phenyl)-2- (4-benzylpiperidin-1-yl) -3-dimethylaminopropan-1-ol, m.p. 132-135° C.

1. customThe organic phase was dried
2. customthe solvent removed