反应详情

To a solution of 2-[(4-ethylphenoxy)methyl]benzoic acid (1.13 g, 4.4 mmol) obtained in Preparation Example 2-1 in chloroform (20 ml) was added oxalyl chloride (0.6 ml, 6.8 mmol) and the mixture was stirred at room temperature for 1 hr. Then the reaction mixture was concentrated under reduced pressure. To the obtained acid chloride were added pyridine (20 ml) and 4,6-diamino-2-methylquinoline (623 mg, 4 mmol) obtained in Preparation Example 1-1 and the mixture was stirred at room temperature for 10 hr. To the reaction mixture was added an aqueous sodium hydrogencarbonate solution and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried over sodium sulfate, and the solvent was evaporated. The obtained crude product was dissolved in ethanol and treated with active charcoal, and the solvent was evaporated. The obtained residue was dissolved in ethyl acetate and 1N hydrochloric acid-ether solution was added. The resulting precipitate was collected by filtration. The obtained solid was heated and dried under reduced pressure to give the title compound (1.06 g, 59%, pale-yellow crystals).

1. concentrationThen the reaction mixture was concentrated under reduced pressure
2. customobtained in Preparation Example 1-1
3. stirringthe mixture was stirred at room temperature for 10 hr
4. extractionthe mixture was extracted with ethyl acetate
5. washThe organic layer was washed with water and saturated brine
6. dry with materialdried over sodium sulfate
7. customthe solvent was evaporated
8. customThe obtained crude product
9. customthe solvent was evaporated
10. dissolutionThe obtained residue was dissolved in ethyl acetate
11. addition1N hydrochloric acid-ether solution was added
12. filtrationThe resulting precipitate was collected by filtration
13. temperatureThe obtained solid was heated
14. customdried under reduced pressure