HRID2188426
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Synthesis was performed from (2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]propanoic acid and 3-phenylpropylamine (41 uL) according to Method A to give the title compound (48 mg). 1H-NMR (400 MHz, CD3OD) d 7.79 (s, 1H), 7.40 (d, J=8.5 Hz, 1H), 7.26-7.13 (m, 10H), 6.99 (d, J=8.5 Hz, 1H), 4.72 (s, 2H), 4.52 (t, J=6.8 Hz, 1H), 4.25 (dd, J=5.3 Hz, J=9.2 Hz, 1H), 3.18 (m, 1H), 3.09-2.92 (m, 4H), 2.77 (dd, J=9.5 Hz, J=13.5 Hz, 1H), 2.50 (t, J=7.7 Hz, 2H), 1.69 (m, 2H), 1.34 (s, 9H); IR (KBr) 3302, 2926, 1736, 1686, 1646 cm−1; HRMS m/z 647.2823 (calc. of monoisotopic mass for C35H41N3O9 gives 647.2823).
WORKUP
后处理
- customSynthesis