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HRID2188432

反应详情

EQUATION

反应方程式

HRID 2188432 的结构方程式

REACTANTS

反应物

2
结构：NCCCN1CCCC1=O
HCID82111

N-(3-Aminopropyl)pyrrolidin-2-one

C7H14N2O

结构：COC(=O)COc1ccc(C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)O)cc1C(=O)OC
HCID57019224

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccc(OCC(=O)O)c(C(=O)O)c1)C(=O)NCCCN1CCCC1=O
HCID57144382

未命名化合物

收率 22.1%

PROCEDURE

实验过程

Synthesis was performed from (2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-[3-(methoxycarbonyl)-4-(2-methoxy-2-oxoethoxy)phenyl]propanoic acid (100 mg, 0.18 mmol) and N-(3′-aminopropyl)-2-pyrrolidinone (42 mg, 0.29 mmol) according to Method C with HPLC purification to give the title compound (26 mg). 1H-NMR (400 MHz, CD3OD) δ 1.35 (s, 9H) 1.6 (m, 2H) 2.03 (m, 2H) 2.37 (t, 2H) 2.76 (m, 1H) 2.92-3.10 (m, 5H) 3.14 (t, 2H) 3.42 (t, 2H) 4.25 (m, 1H) 4.5 (m, 1H) 4.78 (s, 2H) 7.05 (d, 1H) 7.23 (dd, 5H) 7.42 (d, 1H) 7.72 (s, 1H); HR-MS m/z 654.2880 (calc. Of monoisotopic mass for C33H42N4O10 gives 654.2901).

WORKUP

后处理

  1. customSynthesis
  2. customaccording to Method C with HPLC purification