反应详情

Stir a suspension of 1.4 g (85% purity, 3.3 mmol) of 5-(4-ethylphenyl)-6-iodofuro[2,3-d]pyrimidin-4(3H)-one in 20 ml (32.9 g, 214.6 mmol) of phosphoryl chloride under reflux for one hour. After concentrating under reduced pressure, add ice-cold water and dichloromethane to the residue. Dry the organic phase over sodium sulphate and filter. Concentrate the filtrate under reduced pressure and dry. 1.0 g (70% purity, 57% of theory) of the target compound is obtained.

1. temperatureunder reflux for one hour
2. concentrationAfter concentrating under reduced pressure
3. additionadd ice-cold water and dichloromethane to the residue
4. dry with materialDry the organic phase over sodium sulphate
5. filtrationfilter
6. concentrationConcentrate the filtrate under reduced pressure
7. customdry
8. custom1.0 g (70% purity, 57% of theory) of the target compound is obtained