反应详情

Heat 259.8 mg (0.771 mmol) of 4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine and 228 mg of 4-(2-aminophenyl)butanoic acid methyl ester (85% strength, approx. 1.0 mmol) to 150° C. overnight. After cooling, concentrate under reduced pressure, add dichloromethane to the residue and purify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 50:1→10:1). The product thus obtained is purified further by preparative RP-HPLC. 33.1 mg (8.7% of theory) of the target product are obtained.

1. temperatureAfter cooling
2. concentrationconcentrate under reduced pressure
3. additionadd dichloromethane to the residue
4. custompurify the crude product by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 50:1→10:1)
5. customThe product thus obtained
6. customis purified further by preparative RP-HPLC
7. custom33.1 mg (8.7% of theory) of the target product are obtained