反应详情

温度

0 °C

A solution of 2,3,6-trifluoro-5-nitropyridine (1.2 g, 6.7 mmol) in THF (40 ml) was cooled to 0° C. (R)-2-amino-2-(4-fluorophenyl)ethanol (1.0 g, 6.7 mmol) was then added and the reaction was stirred at 0° C. for 30 minutes. The reaction was quenched with water (50 ml) and then extracted with DCM (2×75 ml). The combined organic fractions were dried over Na2SO4, filtered, and then concentrated. The resulting oil was purified by column chromatography (DCM-MeOH=100:1) to give the title compound (1.2 g, 57%). The product was carried over to the next step without characterization.

1. additionwas then added
2. customThe reaction was quenched with water (50 ml)
3. extractionextracted with DCM (2×75 ml)
4. dry with materialThe combined organic fractions were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe resulting oil was purified by column chromatography (DCM-MeOH=100:1)