反应详情

DMAP (0.17 g, 1 0.4 mmol), CDI (0.23 g, 1.4 mmol) and N-(4-(2-aminothiazol-4-yl)phenyl)-methanesulfonamide (0.25 g, 0.93 mmol) were mixed together in DCM/DMF and then stirred overnight at room temperature. After 24 hrs a precipitate had formed. tert-butyl 4-(2-(3,3-diphenylpropylamino)ethyl)piperidine-1-carboxylate (0.39 g, 0.93 mmol) was then added and the resulting mixture stirred for a further 15 hrs. The crude mixture was concentrated under reduced pressure and the residue purified by combi-flash to give tert-butyl 4-(2-(1-(3,3-diphenylpropyl)-3-(4-(4-(methylsulfonamido)phenyl)thiazol-2-yl)ureido)ethyl)piperidine-1-carboxylate 49 as an oily solid.

1. customAfter 24 hrs a precipitate had formed
2. stirringthe resulting mixture stirred for a further 15 hrs
3. concentrationThe crude mixture was concentrated under reduced pressure
4. customthe residue purified by combi-flash