反应详情

8-Bromo-7-methoxy-1H-[1,6]naphthyridin-4-one (12 g, 33.5 mmol) was dissolved in anhydrous methanol (240 mL) and 10% Dry Pd/C (2.4 g) was added carefully in portions. This was followed by portionwise addition of ammonium formate (24 g) which caused an exotherm. The reaction mixture was heated to reflux for 1 h. The reaction mixture was cooled to room temperature, filtered through Celite, and washed with hot methanol. The filtrate was concentrated and the residue purified by column chromatography on silica gel (230-400 mesh) eluting with ethyl acetate-methanol.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 1 h
3. filtrationfiltered through Celite
4. washwashed with hot methanol
5. concentrationThe filtrate was concentrated
6. customthe residue purified by column chromatography on silica gel (230-400 mesh)
7. washeluting with ethyl acetate-methanol