Hydrogen chloride-ethyl acetate → HCID 131730109, compound

HRID 2193183Notes

Reaction equation

HRID 2193183 reaction equation
C(OC(=O)N(CC1C=CC2OCCOC=2C=1)C1CCN(CC[N:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH3:27])[CH:24]=3)[CH:19]=[CH:18][C:17]2=[O:28])CC1)(C)(C)C.[ClH:41].C(OCC)(=O)C>>[ClH:41].[CH3:27][O:26][C:23]1[CH:24]=[C:25]2[C:20]([CH:19]=[CH:18][C:17](=[O:28])[NH:16]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59398114HCID 59398114, compound

Product 1

HCID 131730109HCID 131730109, compound

Procedure

0.29 g of tert-butyl(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(7-methoxy-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate was added to 10 mL of 4 mol/L hydrogen chloride/ethyl acetate solution, and stirred at room temperature for 22 hours. The solvent was removed under reduced pressure, 2-propanol was added to the residue obtained and the resulting solid was filtered to afford 0.20 g of 1-(2-(4-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-7-methoxyquinolin-2(1H)one hydrochloride as a pale yellowish white solid.

Workup

  1. customThe solvent was removed under reduced pressure, 2-propanol
  2. additionwas added to the residue
  3. customobtained
  4. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-36768eba033247bc84a5a1640b59df3f
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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