HRID2193738

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID350056

3-(Methyl(phenyl)amino)-3-oxopropanoic acid

C10H11NO3

结构：COc1ccccc1NC(=O)CC(=O)Nc1ccc(Oc2ccnc3cc(C(=O)NN(C)C)sc23)c(F)c1

HCID16040873

未命名化合物

PRODUCTS

生成物

结构：CN(C)NC(=O)c1cc2nccc(Oc3ccc(NC(=O)CC(=O)N(C)c4ccccc4)cc3F)c2s1

HCID16040874

未命名化合物

收率 44%

PROCEDURE

实验过程

Following the procedure described above for compound 236 (example 95, scheme 63) but replacing acid 27 with 3-(methyl(phenyl)amino)-3-oxopropanoic acid (31), title compound 240 was obtained in 44% yield. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 10.36 (s, 1H), 10.08 (br, 0.3H), 9.52 (s, 0.7H), 8.58 (dd, J=5.5 Hz, 3=8.4 Hz, 1H), 8.20 (m, 1H), 7.79 (m, 1H), 7.49-7.30 (m, 7H), 6.75 (d, J=5.5 Hz, 1H), 3.21 (s, 2H), 3.2 (s, 3H), 2.64 (s, 3H) 2.59 (s, 3H). MS (m/z): (M+1) 522.1 (100%).