huagongshe.com
HRID2194564

反应详情

EQUATION

反应方程式

HRID 2194564 的结构方程式

REACTANTS

反应物

2
结构：Clc1ncc(Br)c(Cl)n1
HCID289973

5-Bromo-2,4-dichloropyrimidine

C4HBrCl2N2

结构：CC(C)(C)OC(=O)N1CC[C@@H](CO)C1
HCID1514340

tert-Butyl (3R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

C10H19NO3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CC[C@@H](COc2nc(Cl)ncc2Br)C1
HCID86761725

未命名化合物

PROCEDURE

实验过程

Using the procedure of Example 1 Step 1, 5-bromo-2,4-dichloropyrimidine was reacted with (R)-tert-butyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate to provide the title compound. 1H NMR (CDCl3, 400 MHz) δ 8.42 (s, 1H), 4.10 (m, 2H), 3.62-3.17 (m, 5H), 2.72-2.69 (m, 1H), 2.10-2.05 (m, 2H), 1.80-1.75 (m, 1H), 1.44 (s, 9H); MS (ESI) m/z: Calc: 392.68 (M). Found. 337.9 (M+-(CH3)3C).