反应详情

Heat a mixture of 4-chloro-6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine (1.30 g, 4.44 mmol), 1-(5-bromo-3-methyl-pyridin-2-yl)-3-(R)-methyl-piperazine (1.2 g, 4.44 mmol), and NaHCO3 (0.71 g, 8.46 mmol) in EtOH at 50° C. for 20 h. Concentrate under reduced pressure and partition between EtOAc and brine. Dry the organic layer (Na2SO4) and concentrate under reduced pressure. Purify the residue by flash column chromatography eluting with EtOAc-hexanes (1:4) to afford the title compound as a white solid.

1. temperatureHeat
2. concentrationConcentrate under reduced pressure
3. custompartition between EtOAc and brine
4. dry with materialDry the organic layer (Na2SO4)
5. concentrationconcentrate under reduced pressure
6. customPurify the residue by flash column chromatography
7. washeluting with EtOAc-hexanes (1:4)