反应详情

4.99 g of [3-(6-aminopyridin-3-yl)phenyl]methanol are placed in a round-bottomed flask and dissolved in 240 ml of tetrahydrofuran. 2.2 g of 1H-imidazole are added thereto, followed by 4.51 g of tert-butyldimethylsilane chloride, and the mixture is left to stir at ambient temperature for 48 hours. The reaction mixture is then hydrolysed with water, and the organic phase, which has been extracted with ethyl acetate, is separated, dried over magnesium sulphate and concentrated under reduced pressure. The residue obtained is purified by silica gel chromatography, elution being carried out with a heptane/ethyl acetate mixture. 7.0 g of compound are obtained.

1. waitthe mixture is left
2. extractionhydrolysed with water, and the organic phase, which has been extracted with ethyl acetate
3. customis separated
4. dry with materialdried over magnesium sulphate
5. concentrationconcentrated under reduced pressure
6. customThe residue obtained
7. customis purified by silica gel chromatography, elution