4-(6-(Methylsulfonyloxy)benzo(b)thiophen-2-yl)phenyl methanesulfonate → HCID 131712869, compound

HRID 2198604Notes

Reaction equation

HRID 2198604 reaction equation
[ClH:1].[O:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][CH:12]=2)[CH2:4][CH2:3]1.[CH3:20][S:21]([O:24][C:25]1[CH:26]=[CH:27][C:28]2[CH:32]=[C:31]([C:33]3[CH:38]=[CH:37][C:36]([O:39][S:40]([CH3:43])(=[O:42])=[O:41])=[CH:35][CH:34]=3)[S:30][C:29]=2[CH:44]=1)(=[O:23])=[O:22]>>[ClH:1].[CH3:20][S:21]([O:24][C:25]1[CH:26]=[CH:27][C:28]2[C:32]([C:15](=[O:17])[C:14]3[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][N:5]4[CH2:4][CH2:3][O:2][CH2:7][CH2:6]4)=[CH:19][CH:18]=3)=[C:31]([C:33]3[CH:34]=[CH:35][C:36]([O:39][S:40]([CH3:43])(=[O:41])=[O:42])=[CH:37][CH:38]=3)[S:30][C:29]=2[CH:44]=1)(=[O:22])=[O:23]

Participants

3

Reactant 2

HCID 132860414-(6-(Methylsulfonyloxy)benzo(b)thiophen-2-yl)phenyl methanesulfonateHCID 161118744-[2-(Morpholin-4-yl)ethoxy]benzoic acid--hydrogen chloride (1/1)

Product 1

HCID 131712869HCID 131712869, compound

Procedure

The process of Example 7 was used to prepare the above product, starting with 7.2 g. of 4-(2-morpholinoethoxy)benzoic acid, hydrochloride, and 5 g. of 6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)benzo[b]thiophene. A yield of 4.25 g. of recrystallized product was obtained, of which 1.25 g. was purified by chromatography as explained in Example 7 above to obtain 0.9 g. of highly purified product, m.p. 197°-200°.

Workup

  1. customto prepare the above product
  2. customof recrystallized product was obtained, of which 1.25 g
  3. customwas purified by chromatography
  4. customto obtain 0.9 g

Sources & evidence

ORD record
ord-195fbd41cd1a487098b50b99509cb1a6
Source dataset
uspto-grants-1982_11
Patent number
US04358593

Reaction notes

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